E-CIGARETTE

E-CIGARETTE: TOXIC COMPONENTS AND CARDIOPULMONARY EFFECTS OF INHALING ITS AEROSOLS - LITERATURE REVIEW FROM 2019-2024

Authors

  • ANLLY AÑEZ Latina University of Panama, teaching doctor. Panama, Panama City.
  • MARTA ESTELA BERGUIDO DE LA GUARDIA Latina University of Panama, student of the Doctor of Medicine and Surgery degree. Panama, Panama City.
  • ISABEL VICTORIA BULLEN ZARAK Latina University of Panama, student of the Doctor of Medicine and Surgery degree. Panama, Panama City.
  • ALEJANDRO AUGUSTO FÁBREGA Latina University of Panama, student of the Doctor of Medicine and Surgery degree. Panama, Panama City.
  • GASPAR MORÁN Latina University of Panama, student of the Doctor of Medicine and Surgery degree. Panama, Panama City.
  • CÉSAR AUGUSTO SÁNCHEZ Latina University of Panama, student of the Doctor of Medicine and Surgery degree. Panama, Panama City.

Keywords:

Electronic cigarettes, vaping, e-liquid, inflammatory cytokines, EVALI, endothelial dysfunction, atherosclerosis.

Abstract

In 2003, electronic cigarettes (ECs) were created to assist smokers in quitting tobacco. Since then, numerous vaping devices with appealing flavored "e-liquids" have emerged, particularly targeting adolescents. Despite sales regulations, it is estimated that 6% of young Panamanians use these devices, underscoring the need to study their health effects. This literature review details the components of ECs and their cardiopulmonary effects. Nicotine is highlighted as a cause of oxidative stress and endothelial dysfunction, potentially leading to cardiovascular diseases. Conversely, flavorings, formaldehyde, acrolein, and other aerosol components of ECs induce pulmonary and vascular toxicity through an inflammatory reaction mediated by IL-6 and IL-8, immune cells, and enzymes. This affects the pulmonary mucociliary system and predisposes users to obstructive pulmonary diseases like COPD. Although the chronic effects of ECs are unknown, some flavorings have been linked to lipid pneumonia or "popcorn lung," as well as EVALI (Electronic Cigarette or Vaping Product Use-Associated Lung Injury), studied after numerous cases in 2019. Studied acute effects of ECs indicate health risks, hence it's recommended that young individuals educate themselves and refrain from using these devices.

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References

Aherrera, A., Olmedo, P., Grau-Perez, M., Tanda, S., Goessler, W., Jarmul, S., Chen, R., Cohen, J. E., Rule, A. M., & Navas-Acien, A. (2017). The association of e-cigarette use with exposure to nickel and chromium: A preliminary study of non-invasive biomarkers. Environmental Research, 159, 313-320. https://doi.org/10.1016/j.envres.2017.08.014

Alzahrani, T. (2023). Electronic Cigarette Use and Myocardial Infarction. Cureus, 15(11), e48402. https://doi.org/10.7759/cureus.48402

American Cancer Society. (2020, October 28). Harmful Chemicals in Tobacco Products | American Cancer Society. Www.cancer.org. https://www.cancer.org/cancer/risk-prevention/tobacco/carcinogens-found-in-tobacco-products.html#:~:text=Tobacco%20smoke%20is%20made%20up

American Lung Association. (n.d.). Lung Health & Diseases | American Lung Association. Www.lung.org. https://www.lung.org/lung-health-diseases/lung-disease-lookup/evali

Antoniewicz, L., Brynedal, A., Hedman, L., Lundbäck, M., & Bosson, J. A. (2019). Acute Effects of Electronic Cigarette Inhalation on the Vasculature and the Conducting Airways. Cardiovascular Toxicology, 19(5), 441–450. https://doi.org/10.1007/s12012-019-09516-x

Arastoo, S., Haptonstall, K. P., Choroomi, Y., Moheimani, R., Nguyen, K., Tran, E., Gornbein, J., & Middlekauff, H. R. (2020). Acute and chronic sympathomimetic effects of e-cigarette and tobacco cigarette smoking: role of nicotine and non-nicotine constituents. American Journal of Physiology-Heart and Circulatory Physiology, 319(2), H262–H270. https://doi.org/10.1152/ajpheart.00192.2020

Ashraf, M. T., Shaikh, A., Khan, M. K. S., Uddin, N., Kashif, M. A. B., Rizvi, S. H. A., Khalid, H., Sam, S. J., & Sohail, A. (2023). Association between e-cigarette use and myocardial infarction: a systematic review and meta-analysis. The Egyptian Heart Journal: (EHJ): Official Bulletin of the Egyptian Society of Cardiology, 75(1), 97. https://doi.org/10.1186/s43044-023-00426-6

Auschwitz E, Almeda J, Andl CD. Mechanisms of E-cigarette vape-induced epithelial cell damage. Cells [Internet]. 2023;12(21):2552. Disponible en: http://dx.doi.org/10.3390/cells12212552

Azimi, P., Keshavarz, Z., Lahaie Luna, M., Cedeno Laurent, J. G., Vallarino, J., Christiani, D. C., & Allen, J. G. (2021). An unrecognized hazard in e-cigarette vapor: Preliminary quantification of methylglyoxal formation from propylene glycol in e-cigarettes. International Journal of Environmental Research and Public Health, 18(2), 385

Bahl, V., Lin, S., Xu, N., Davis, B., Wang, Y. H., & Talbot, P. (2012). Comparison of electronic cigarette refill fluid cytotoxicity using embryonic and adult models. Reproductive Toxicology, 34(4), 529–537. https://doi.org/10.1016/j.reprotox.2012.08.001

Belkin, S., Benthien, J., Axt, P. N., Mohr, T., Mortensen, K., Weckmann, M., Drömann, D., & Franzen, K. F. (2023). Impact of heated tobacco products, E-cigarettes, and cigarettes on inflammation and endothelial dysfunction. International Journal of Molecular Sciences, 24(11), 9432. https://doi.org/10.3390/ijms24119432

Bernhard, D., Csordas, A., Henderson, B., Rossmann, A., Kind, M., & Wick, G. (2005). Cigarette smoke metal-catalyzed protein oxidation leads to vascular endothelial cell contraction by depolymerization of microtubules. FASEB Journal, 19(9), 1096–1107. https://doi.org/10.1096/fj.04-3192com

Berry, J. D., Dyer, A., Cai, X., Garside, D. B., Ning, H., Thomas, A., Greenland, P., Van Horn, L., Tracy, R. P., & Lloyd-Jones, D. M. (2012). Lifetime Risks of Cardiovascular Disease. New England Journal of Medicine, 366(4), 321–329. https://doi.org/10.1056/nejmoa1012848

Biondi‐Zoccai, G., Sciarretta, S., Bullen, C., Nocella, C., Violi, F., Loffredo, L., Pignatelli, P., Perri, L., Peruzzi, M., Marullo, A. G. M., De Falco, E., Chimenti, I., Cammisotto, V., Valenti, V., Coluzzi, F., Cavarretta, E., Carrizzo, A., Prati, F., Carnevale, R., & Frati, G. (2019). Acute Effects of Heat‐Not‐Burn, Electronic Vaping, and Traditional Tobacco Combustion Cigarettes: The Sapienza University of Rome‐Vascular Assessment of Proatherosclerotic Effects of Smoking (SUR‐VAPES) 2 Randomized Trial. Journal of the American Heart Association, 8(6). https://doi.org/10.1161/jaha.118.010455

Blagev, D. P., Harris, D., Dunn, A. C., Guidry, D. W., Grissom, C. K., & Lanspa, M. J. (2019b). Clinical presentation, treatment, and short-term outcomes of lung injury associated with e-cigarettes or vaping: a prospective observational cohort study. The Lancet, 394(10214). https://doi.org/10.1016/s0140-6736(19)32679-0

Cao, D. J., Aldy, K., Hsu, S., McGetrick, M., Verbeck, G., De Silva, I., & Feng, S. (2020). Review of Health Consequences of Electronic Cigarettes and the Outbreak of Electronic Cigarette, or Vaping, Product Use-Associated Lung Injury. Journal of Medical Toxicology, 16(3), 295–310. https://doi.org/10.1007/s13181-020-00772-w

Carrasco, J. R., Vázquez, H. O.-0003-3352-2860 L. C. L., Fajardo-Rodríguez, H. O.-0002-7420-0545 L. M., & Rondón-Carrasco, H. O.-0003-4744-6045 L. R. (s/f). EFECTO SOBRE LA SALUD DE LOS CIGARRILLOS ELECTRÓNICOS. 2021, https://www.eumed.net/uploads/articulos/29acad3a9a4b2f354458dd464bc4fa5e.pdf

Carvajal, C. (2017). El endotelio: estructura, función y disfunción endotelial. Medicina Legal de Costa Rica, 34(2), 90–100. https://www.scielo.sa.cr/scielo.php?script=sci_arttext&pid=S1409-00152017000200090#:~:text=La%20disfunci%C3%B3n%20endotelial%20(DE)%20comprende

Chen, E. Y., Sun, A., Chen, C. S., Mintz, A. J., & Chin, W. C. (2014). Nicotine alters mucin rheological properties. American Journal of Physiology. Lung Cellular and Molecular Physiology, 307(2), L149–L157. https://doi.org/10.1152/ajplung.00396.2012

Consequences, I. (s/f). Consumo del cigarro electrónico en adolescentes y sus consecuencias Ugto.mx. 2024, de http://repositorio.ugto.mx/bitstream/20.500.12059/9810/1/229Consumo%20del%20cigarro%20electr%c3%b3nico%20en%20adolescentes%20y%20sus%20consecuencias.pdf

Control del tabaco. (s/f). Paho.org. 2024 https://www.paho.org/es/temas/control-tabaco

De Jbde, D. l3. (s/f). REPÚBLICA DE PANAMÁ MINISTERIO DE SALUD. Corprensa.com. 2024, de https://cdn.corprensa.com/la-prensa/uploads/2023/09/25/decreto_ejecutivo_no_34_de_13_de_julio_de_2023_-_reglamenta_ley_315_de_30_de_junio_de_2022_prohibe_uso_importacion_de_cigarrilos_electronicos_-_normativa%20(1).pdf

Ecotvpanama. (2023). Panamá aumenta el contrabando de cigarrillos electrónicos. https://www.ecotvpanama.com/nacionales/panama-aumenta-el-contrabando-cigarrillos-electronicos-n5891127

Eltorai AEM, Choi AR, Eltorai AS. Impact of electronic cigarettes on various organ systems. Respir Care [Internet]. 2019;64(3):328–36. Disponible en: http://dx.doi.org/10.4187/respcare.06300

Esteban-Lopez, M., Perry, M. D., Garbinski, L. D., Manevski, M., Andre, M., Ceyhan, Y., Caobi, A., Paul, P., Lau, L. S., Ramelow, J., Owens, F., Souchak, J., Ales, E., & El-Hage, N. (2022b). Health effects and known pathology associated with the use of E-cigarettes. Toxicology Reports, 9, 1357–1368. https://doi.org/10.1016/j.toxrep.2022.06.006

Evans-Polce, R. J., Patrick, M. E., Lanza, S. T., Miech, R. A., O'Malley, P. M., & Johnston, L. D. (2018). Reasons for vaping among U.S. 12th graders. Journal of Adolescent Health, 62(4), 457–462. https://doi.org/10.1016/j.jadohealth.2017.10.009

Farsalinos, K. E., Polosa, R., Cibella, F., & Niaura, R. (2019). Is e-cigarette use associated with coronary heart disease and myocardial infarction? Insights from the 2016 and 2017 National Health Interview Surveys. Therapeutic Advances in Chronic Disease, 10, 204062231987774. https://doi.org/10.1177/2040622319877741

Fathima, S., & Zhang, H. (2020). Histologic patterns of lung injury in patients using e-cigarettes. Proceedings (Baylor University. Medical Center), 33(4), 619–620. https://doi.org/10.1080/08998280.2020.1775052

Fetterman, J. L., Weisbrod, R. M., Feng, B., Bastin, R., Tuttle, S. T., Holbrook, M., Baker, G., Robertson, R. M., Conklin, D. J., Bhatnagar, A., & Hamburg, N. M. (2018). Flavorings in tobacco products induce endothelial cell dysfunction. Arteriosclerosis, Thrombosis, and Vascular Biology, 38(7), 1607–1615. https://doi.org/10.1161/ATVBAHA.118.311156

Forder, A., Zhuang, R., Souza, V. G. P., Brockley, L. J., Pewarchuk, M. E., Telkar, N., Stewart, G. L., Benard, K., Marshall, E. A., Reis, P. P., & Lam, W. L. (2023). Mechanisms contributing to the comorbidity of COPD and lung cancer. International Journal of Molecular Sciences, 24(3). https://doi.org/10.3390/ijms24032859

Furman D, Campisi J, Verdin E, Carrera-Bastos P, Targ S, Franceschi C, et al. Chronic inflammation in the etiology of disease across the life span. Nat Med [Internet]. 2019;25(12):1822–32. Disponible en: http://dx.doi.org/10.1038/s41591-019-0675-0

Garcia-Arcos, I., Geraghty, P., Baumlin, N., Campos, M., Dabo, A. J., Jundi, B., Cummins, N., Eden, E., Grosche, A., Salathe, M., et al. (2016). Chronic electronic cigarette exposure in mice induces features of COPD in a nicotine-dependent manner. Thorax, 71, 1119–1129. https://doi.org/10.1136/thoraxjnl-2015-208039

George, J., Hussain, M., Vadiveloo, T., Ireland, S., Hopkinson, P., Struthers, A. D., Donnan, P. T., Khan, F., & Lang, C. C. (2019). Cardiovascular Effects of Switching From Tobacco Cigarettes to Electronic Cigarettes. Journal of the American College of Cardiology, 74(25), 3112–3120. https://doi.org/10.1016/j.jacc.2019.09.067

Gómez Cerezo, J. F., López Paz, J. E., & Fernández Pardo, J. (2022). Actualización sobre las nuevas formas de consumo de tabaco. Clínica e Investigación en Arteriosclerosis, 34(6), 330–338. https://doi.org/10.1016/j.arteri.2022.03.004

Gonzalez, J. E., & Cooke, W. H. (2021). Acute effects of electronic cigarettes on arterial pressure and peripheral sympathetic activity in young nonsmokers. American Journal of Physiology. Heart and Circulatory Physiology, 320(1), H248–H255. https://doi.org/10.1152/ajpheart.00448.2020

Guo, Q., Wang, J., Liu, H., Wu, D., & Liao, S. (2022). Nicotine Ingestion Reduces Heart Rate Variability in Young Healthy Adults. BioMed Research International, 2022, 1–7. https://doi.org/10.1155/2022/4286621

Hamberger, E. S., & Halpern-Felsher, B. (2020). Vaping in adolescents: epidemiology and respiratory harm. Current Opinion in Pediatrics, 32(3), 378–383. https://doi.org/10.1097/mop.0000000000000896

Herman, M., & Tarran, R. (2020). E-cigarettes, nicotine, the lung and the brain: multi-level cascading pathophysiology. The Journal of Physiology, 598(22), 5063–5071. https://doi.org/10.1113/JP278388

Hill, D. B., Button, B., Rubinstein, M., & Boucher, R. C. (2022). Physiology and pathophysiology of human airway mucus. Physiological Reviews, 102(4), 1757–1836. https://doi.org/10.1152/physrev.00004.2021

Jiang, Y., Dai, A., Zhou, Y., et al. (2014). Nicotine elevated intracellular Ca(2)(+) in rat airway smooth muscle cells via activating and up-regulating alpha7-nicotinic acetylcholine receptor. Cellular Physiology and Biochemistry, 33, 389–401. https://doi.org/10.1159/000356678

Jonas, A. (2022). Impact of vaping on respiratory health. BMJ, 378(378), e065997. https://doi.org/10.1136/bmj-2021-065997

Kalininskiy, A., Bach, C. T., Nacca, N. E., Ginsberg, G., Marraffa, J., Navarette, K. A., McGraw, M. D., & Croft, D. P.(2019). E-cigarette, or vaping, product use associated lung injury (EVALI): case series and diagnostic approach. The Lancet Respiratory Medicine, 7(12). https://doi.org/10.1016/s2213-2600(19)30415-1

Kaur, S., Bansal, Y., Kumar, R., & Bansal, G. (2020). A panoramic review of IL-6: Structure, pathophysiological roles and inhibitors. Bioorganic & Medicinal Chemistry, 28(5), 115327. https://doi.org/10.1016/j.bmc.2020.115327

Kennedy, C. D., van Schalkwyk, M. C. I., McKee, M., & Pisinger, C. (2019). The cardiovascular effects of electronic cigarettes: A systematic review of experimental studies. Preventive Medicine, 127, 105770. https://doi.org/10.1016/j.ypmed.2019.105770

Khadka, S., Awasthi, M., Lamichhane, R. R., Ojha, C., Mamudu, H. M., Lavie, C. J., Daggubati, R., & Paul, T. K. (2021). The Cardiovascular Effects of Electronic Cigarettes. Current Cardiology Reports, 23(5), 40. https://doi.org/10.1007/s11886-021-01469-4

Klonizakis, M., Gumber, A., McIntosh, E., & Brose, L. S. (2022). Medium- and longer-term cardiovascular effects of e-cigarettes in adults making a stop-smoking attempt: a randomized controlled trial. BMC Medicine, 20(1). https://doi.org/10.1186/s12916-022-02451-9

Komura, M., Sato, T., Yoshikawa, H., Nitta, N. A., Suzuki, Y., Koike, K., Kodama, Y., Seyama, K., & Takahashi, K. (2022). Propylene glycol, a component of electronic cigarette liquid, damages epithelial cells in human small airways. Respiratory Research, 23(1), 216. https://doi.org/10.1186/s12931-022-02142-2

Kuntic, M., Oelze, M., Steven, S., Kröller-Schön, S., Stamm, P., Kalinovic, S., Frenis, K., Vujacic-Mirski, K., Bayo Jimenez, M. T., Kvandova, M., Filippou, K., Al Zuabi, A., Brückl, V., Hahad, O., Daub, S., Varveri, F., Gori, T., Huesmann, R., ... Münzel, T. (2020). Short-term e-cigarette vapour exposure causes vascular oxidative stress and dysfunction: Evidence for a close connection to brain damage and a key role of the phagocytic NADPH oxidase (NOX-2). European Heart Journal, 41(26), 2472–2483. https://doi.org/10.1093/eurheartj/ehz772

Landman, S. T., Dhaliwal, I., Mackenzie, C. A., Martinu, T., Steele, A., & Bosma, K. J. (2019). Life-threatening bronchiolitis related to electronic cigarette use in a Canadian youth. Canadian Medical Association Journal, 191(48), E1321–E1331. https://doi.org/10.1503/cmaj.191402

Layden, J. E., Ghinai, I., Pray, I., Kimball, A., Layer, M., Tenforde, M., Navon, L., Hoots, B., Salvatore, P. P., Elderbrook, M., Haupt, T., Kanne, J., Patel, M. T., Saathoff-Huber, L., King, B. A., Schier, J. G., Mikosz, C. A., & Meiman, J. (2019). Pulmonary Illness Related to E-Cigarette Use in Illinois and Wisconsin — Preliminary Report. New England Journal of Medicine, 382(10). https://doi.org/10.1056/nejmoa1911614

Lee, H. W., Park, S. H., Weng, M. W., et al. (2018). E-cigarette smoke damages DNA and reduces repair activity in mouse lung, heart, and bladder as well as in human lung and bladder cells. Proceedings of the National Academy of Sciences of the United States of America, 115(7), E1560-E1569. https://doi.org/10.1073/pnas.1718185115

Lee, W. H., Ong, S. G., Zhou, Y., Tian, L., Bae, H. R., Baker, N., Whitlatch, A., Mohammadi, L., Guo, H., Nadeau, K. C., Springer, M. L., Schick, S. F., Bhatnagar, A., & Wu, J. C. (2019). Modeling cardiovascular risks of e-cigarettes with human-induced pluripotent stem cell-derived endothelial cells. Journal of the American College of Cardiology, 73(21), 2722–2737. https://doi.org/10.1016/j.jacc.2019.03.476

Llambí, L., Rodríguez, D., Parodi, C., & Soto, E. (2020). Cigarrillo electrónico y otros sistemas electrónicos de liberación de nicotinarevisión de evidencias sobre un tema controversial. La Revista medica del Uruguay, 36(1). https://doi.org/10.29193/rmu.36.1.7

Lyu, J. C., Olson, S. S., Ramo, D. E., & Ling, P. M. (2022). Delivering vaping cessation interventions to adolescents and young adults on Instagram: Protocol for a randomized controlled trial. BMC Public Health, 22(1), 2311. https://doi.org/10.1186/s12889-022-14606-7

Lyytinen, G., Brynedal, A., Anesäter, E., Antoniewicz, L., Blomberg, A., Wallén, H., Bosson, J. A., Hedman, L., Mobarrez, F., Tehrani, S., & Lundbäck, M. (2023). Electronic Cigarette Vaping with Nicotine Causes Increased Thrombogenicity and Impaired Microvascular Function in Healthy Volunteers: A Randomised Clinical Trial. Cardiovascular Toxicology, 23(7-8), 255–264. https://doi.org/10.1007/s12012-023-09802-9

Maffit, S. K., Sellitto, A. D., Al-Dadah, A. S., Schuessler, R. B., Damiano, R. J., Jr, & Lawton, J. S. (2012). Diazoxide maintains human myocyte volume homeostasis during stress. Journal of the American Heart Association, 1(2). https://doi.org/10.1161/jaha.112.000778

Mandal, A., MD. (n.d.). Nicotine and Oxidative Stress. In Robertson, S., B.Sc. (Ed.), News-Medical. 2024, from https://www.news-medical.net/health/Nicotine-and-Oxidative-Stress.aspx

Mantovani, A., Dinarello, C. A., Molgora, M., & Garlanda, C. (2019). Interleukin-1 and related cytokines in the regulation of inflammation and immunity. Immunity, 50(4), 778–795. https://doi.org/10.1016/j.immuni.2019.03.012

Marrocco, A., Singh, D., Christiani, D. C., & Demokritou, P. (2022). E-cigarette vaping associated acute lung injury (EVALI): state of science and future research needs. Critical Reviews in Toxicology, 52(3), 188–220. https://doi.org/10.1080/10408444.2022.2082918

Martin-Cantera, C., Fernández, J. L., & Villalbi, y. J. R. (s/f). CIGARRILLOS ELECTRÓNICOS. Core.ac.uk. 2024, de https://core.ac.uk/download/pdf/347139273.pdf

Mattingly, D. T., & Hart, J. L. (2024). Trends in current electronic cigarette use among youths by age, sex, and race and ethnicity. JAMA Network Open, 7(2), e2354872. https://doi.org/10.1001/jamanetworkopen.2023.54872

Middlekauff, H. R. (2019). Cardiovascular impact of electronic-cigarette use. Trends in Cardiovascular Medicine, 30(3). https://doi.org/10.1016/j.tcm.2019.04.006

Miyashita, L., & Foley, G. (2020). E‐cigarettes and respiratory health: the latest evidence. The Journal of Physiology, 598(22), 5027–5038. https://doi.org/10.1113/jp279526

Mobarrez, F., Antoniewicz, L., Hedman, L., Bosson, J. A., & Lundbäck, M. (2020). Electronic cigarettes containing nicotine increase endothelial and platelet derived extracellular vesicles in healthy volunteers. Atherosclerosis, 301, 93–100. https://doi.org/10.1016/j.atherosclerosis.2020.02.010

Mucha, L., Stephenson, J., Morandi, N., & Dirani, R. (2006). Meta-analysis of disease risk associated with smoking, by gender and intensity of smoking. Gender Medicine, 3(4), 279–291. https://doi.org/10.1016/s1550-8579(06)80216-0

Mukhopadhyay, S., Mehrad, M., Dammert, P., Arrossi, A. V., Sarda, R., Brenner, D. S., Maldonado, F., Choi, H., & Ghobrial, M. (2019). Lung biopsy findings in severe pulmonary illness associated with E-cigarette use (vaping). American Journal of Clinical Pathology. https://doi.org/10.1093/ajcp/aqz182

Oliveira, C., Silveira, E. A., Rosa, L., Santos, A., Rodrigues, A. P., Mendonça, C., Silva, L., Gentil, P., & Rebelo, A. C. (2020). Risk Factors Associated with Cardiac Autonomic Modulation in Obese Individuals. Journal of Obesity, 2020, 1–8. https://doi.org/10.1155/2020/7185249

Palmer, A. M., Price, S. N., Foster, M. G., Sanford, B. T., Fucito, L. M., & Toll, B. A. (2022). Urgent Need for Novel Investigations of Treatments to Quit E-cigarettes: Findings from a Systematic Review. Cancer Prevention Research (Philadelphia), 15(9), 569-580.

Panamá, T. (2023, septiembre 28). Vapeo, moda peligrosa. Tvn Panamá. https://www.tvn-2.com/contenido-exclusivo/vapeo-moda-peligrosa-cigarrillos-electronicos_1_2081260.html

Panse, P. M., Feller, F. F., Butt, Y. M., Smith, M. L., Larsen, B. T., Tazelaar, H. D., Harvin, H. J., & Gotway, M. B. (2020). Radiologic and pathologic correlation in EVALI. AJR. American Journal of Roentgenology, 215(5), 1057–1064. https://doi.org/10.2214/ajr.20.22836

Parekh, T., Pemmasani, S., & Desai, R. (2020). Risk of Stroke With E-Cigarette and Combustible Cigarette Use in Young Adults. American Journal of Preventive Medicine, 58(3). https://doi.org/10.1016/j.amepre.2019.10.008

Park J-A, Crotty Alexander LE, Christiani DC. Vaping and lung inflammation and injury. Annu Rev Physiol [Internet]. 2022;84(1):611–29. Disponible en: http://dx.doi.org/10.1146/annurev-physiol-061121-040014

Perez, C. M., Hazari, M. S., Ledbetter, A. D., Haykal-Coates, N., Carll, A. P., Cascio, W. E., Winsett, D. W., Costa, D. L., & Farraj, A. K. (2015). Acrolein inhalation alters arterial blood gases and triggers carotid body-mediated cardiovascular responses in hypertensive rats. Inhalation Toxicology, 27(1), 54–63. https://doi.org/10.3109/08958378.2014.984881

Prasad, D. S., Kabir, Z., Dash, A. K., & Das, B. C. (2009). Smoking and cardiovascular health: a review of the epidemiology, pathogenesis, prevention and control of tobacco. Indian Journal of Medical Sciences, 63(11), 520–533. https://pubmed.ncbi.nlm.nih.gov/20075556/

Ruszkiewicz, J. A., Zhang, Z., Gonçalves, F. M., Tizabi, Y., Zelikoff, J. T., & Aschner, M. (2020). Neurotoxicity of e-cigarettes. Food and Chemical Toxicology, 138, 111245. https://doi.org/10.1016/j.fct.2020.111245

Sayegh, A., Faroze, F., Paton, J., & Fisher, J. (2023). Arterial stiffness and peripheral chemoreflex responsiveness in electronic cigarette users. Physiology, 38(S1). https://doi.org/10.1152/physiol.2023.38.s1.5734086

Seiler-Ramadas R, Sandner I, Haider S, Grabovac I, Dorner TE. Health effects of electronic cigarette (e‑cigarette) use on organ systems and its implications for public health. Wien Klin Wochenschr [Internet]. 2021;133(19–20):1020–7. Disponible en: http://dx.doi.org/10.1007/s00508-020-01711-z

Shao, B., Fu, X., McDonald, T. O., Green, P. S., Uchida, K., O'Brien, K. D., Oram, J. F., & Heinecke, J. W. (2005). Acrolein impairs ATP binding cassette transporter A1-dependent cholesterol export from cells through site-specific modification of apolipoprotein A-I. Journal of Biological Chemistry, 280(43), 36386–36396. https://doi.org/10.1074/jbc.M508169200

Sithu, S. D., Srivastava, S., Siddiqui, M. A., Vladykovskaya, E., Riggs, D. W., Conklin, D. J., Haberzettl, P., O'Toole, T. E., Bhatnagar, A., & D'Souza, S. E. (2010). Exposure to acrolein by inhalation causes platelet activation. Toxicology and Applied Pharmacology, 248(2), 100–110. https://doi.org/10.1016/j.taap.2010.07.013

Smith, M. L., Gotway, M. B., Crotty Alexander, L. E., & Hariri, L. P. (2020). Vaping-related lung injury. Virchows Archiv: An International Journal of Pathology, 478(1), 81–88. https://doi.org/10.1007/s00428-020-02943-0

Stefaniak, A. B., LeBouf, R. F., Ranpara, A. C., & Leonard, S. S. (2021). Toxicology of flavoring- and cannabis-containing e-liquids used in electronic delivery systems. Pharmacology & Therapeutics, 224, 107838. https://doi.org/10.1016/j.pharmthera.2021.107838

Subedi, L., Lee, S. E., Madiha, S., Gaire, B. P., Jin, M., Yumnam, S., & Kim, S. Y. (2020). Phytochemicals against TNFα-mediated neuroinflammatory diseases. International Journal of Molecular Sciences, 21(3), 764. https://doi.org/10.3390/ijms21030764

Takeshita, D., Nakajima-Takenaka, C., Shimizu, J., Hattori, H., Nakashima, T., Kikuta, A., Matsuyoshi, H., & Takaki, M. (2009). Effects of formaldehyde on the cardiovascular system in in situ rat hearts. Basic & Clinical Pharmacology & Toxicology, 105(4), 271–280. https://doi.org/10.1111/j.1742-7843.2009.00442.x

Tattersall, M. C., Hughey, C. M., Piasecki, T. M., Korcarz, C. E., Hansen, K. M., Ott, N. R., Sandbo, N., Fiore, M. C., Baker, T. B., & Stein, J. H. (2023). Cardiovascular and Pulmonary Responses to Acute Use of Electronic Nicotine Delivery Systems and Combustible Cigarettes in Chronic Users. CHEST, Thoracic Oncology, 164(3). https://doi.org/10.1016/j.chest.2023.03.047

Tsai, M., Byun, M. K., Shin, J., & Crotty Alexander, L. E. (2020). Effects of e‐cigarettes and vaping devices on cardiac and pulmonary physiology. The Journal of Physiology, 598(22). https://doi.org/10.1113/jp279754

Villarreal, F. J., Hong, D., & Omens, J. (1999, March 1). Nicotine-modified postinfarction left ventricular remodeling. American Journal of Physiology-Heart and Circulatory Physiology, 276(3), H1103-H1106. https://doi.org/10.1152/ajpheart.1999.276.3.H1103

Vilotić, A., Nacka-Aleksić, M., Pirković, A., Bojić-Trbojević, Ž., Dekanski, D., & Jovanović Krivokuća, M. (2022). IL-6 and IL-8: An overview of their roles in healthy and pathological pregnancies. International Journal of Molecular Sciences, 23(23), 14574. https://doi.org/10.3390/ijms232314574

Williams, M., Villarreal, A., Bozhilov, K., Lin, S., & Talbot, P. (2013). Metal and silicate particles including nanoparticles are present in electronic cigarette cartomizer fluid and aerosol. PloS One, 8(3), e57987. https://doi.org/10.1371/journal.pone.0057987

Wu, Q., Jiang, D., Minor, M., & Chu, H. W. (2014). Electronic cigarette liquid increases inflammation and virus infection in primary human airway epithelial cells. PLoS One, 9, e108342. https://doi.org/10.1371/journal.pone.0108342

Xu, Y., Li, H., Bajrami, B., et al. (2013). Cigarette smoke (CS) and nicotine delay neutrophil spontaneous death via suppressing production of diphosphoinositol pentakisphosphate. Proceedings of the National Academy of Sciences of the United States of America, 110, 7726–7731. https://doi.org/10.1073/pnas.1302906110

Zhao, K., Li, J., Zhou, P., Xu, L., & Yang, M. (2022). Is electronic cigarette use a risk factor for stroke? A systematic review and meta-analysis. Tobacco Induced Diseases, 20, 101. https://doi.org/10.18332/tid/154364

Zhu, S. H., et al. (2014). Four hundred and sixty brands of e-cigarettes and counting: Implications for product regulation. Tob Control, 23(suppl 3), iii3–9. https://doi.org/10.1136/tobaccocontrol-2014-051670

Published

2024-07-28

How to Cite

AÑEZ, A., BERGUIDO DE LA GUARDIA, M. E., BULLEN ZARAK, I. V., FÁBREGA, A. A., MORÁN, G., & SÁNCHEZ, C. A. (2024). E-CIGARETTE: E-CIGARETTE: TOXIC COMPONENTS AND CARDIOPULMONARY EFFECTS OF INHALING ITS AEROSOLS - LITERATURE REVIEW FROM 2019-2024. Key People, 8(2), 56–98. Retrieved from https://revistas.ulatina.edu.pa/index.php/genteclave/article/view/362

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