DESARROLLO DE HIDROGELES EN APLICACIONES EN BIOMEDICINA
Resumen
Dentro de los biomateriales más ampliamente utilizado en estudios de biomedicina para la regeneración del sistema nervioso se encuentran los hidrogeles y que corresponden a redes polimericas con alta capacidad de absorción de agua. Los hidrogeles son biomateriales capaces de ser incorporados en el cuerpo humano sin generar la perturbación del ecosistema neuronal y promover distintos procesos celulares. Las ventajas del uso de hidrogeles vienen dadas por su gran biocompatibilidad y su gran capacidad regenerativa in situ, lo que los hace excelentes candidatos para aplicaciones en el problemas patológicos humanos. Sus aplicaciones biomédicas son diversas, destacando su papel como sistemas de liberación sostenida de fármacos, lo que representa una alternativa para la regeneración de tejido dañado; además son andamios tridimensionales para diversas terapias celulares, proporcionando un microambiente con propiedades biomiméticas que permite la expresión diferencial de comportamientos celulares que promueven la recuperación del tejido dañado. Esta característica lo hace de alta relevancia en la medicina regenerativa enfocada en la reparación de sistema nervioso en distintas neuropatologías, pues la anatomía de este sistema es altamente compleja y delicada. Actualmente, el estudio de los hidrogeles como posibles biomateriales promotores de la regeneración axonal es un tema muy dinámico y gran potencial en posibles aplicaciones preclinicasDentro de los biomateriales más ampliamente utilizado en estudios de biomedicina para la regeneración del sistema nervioso se encuentran los hidrogeles y que corresponden a redes polimericas con alta capacidad de absorción de agua. Los hidrogeles son biomateriales capaces de ser incorporados en el cuerpo humano sin generar la perturbación del ecosistema neuronal y promover distintos procesos celulares. Las ventajas del uso de hidrogeles vienen dadas por su gran biocompatibilidad y su gran capacidad regenerativa in situ, lo que los hace excelentes candidatos para aplicaciones en el problemas patológicos humanos. Sus aplicaciones biomédicas son diversas, destacando su papel como sistemas de liberación sostenida de fármacos, lo que representa una alternativa para la regeneración de tejido dañado; además son andamios tridimensionales para diversas terapias celulares, proporcionando un microambiente con propiedades biomiméticas que permite la expresión diferencial de comportamientos celulares que promueven la recuperación del tejido dañado. Esta característica lo hace de alta relevancia en la medicina regenerativa enfocada en la reparación de sistema nervioso en distintas neuropatologías, pues la anatomía de este sistema es altamente compleja y delicada. Actualmente, el estudio de los hidrogeles como posibles biomateriales promotores de la regeneración axonal es un tema muy dinámico y gran potencial en posibles aplicaciones preclinicas.
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